I think peri-menopause can do that; it often starts in late 30's and will go through 40's until your menopause. Think back to when you first got your period in your teens and what that was like? Were you anxious then (but more so than now?). I use to get practically suicidal a day or two before my period and so the anxiety and slight depression in my 40's just seemed a milder replay of that.
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