Hi Candy,
I recently had to have my thyroid removed and now take levoxyl (synthyroid) daily. My endo looked at the meds I am now taking (some need to be taken with food for comfort) and said not to worry about taking it with or without food or when I take it...........just to remember to take it .
I have been taking it in the morning with all my other meds but have recently switched to the PM (without food) to see if it helps my mood improve at all.......

Take care!