Hi, BNLsMOM! I was on Depakote for several years, not for bipolar but for neurological and psychiatric stuff. Depakote - I understand - is metabolized in the liver. After over a year of elevated liver enzymes and a liver biopsy indicating the beginning or precursors of cirrhosis, they weaned me off the drug. My liver enzyme levels have returned to normal.

Personally, I never experienced pain. The indication something was wrong came from regular blood tests.