While it's true that you definitely shouldn't take a thyroid hormone replacement at the same time as things like a calcium supplement or down the tablet with a glass of milk, just beware of some of the "wacko" advice I've seen out there (on thyroid forums.)

Some people will tell you that you shouldn't have any calcium within 6 hours of taking a thyroid supplement! One person wrote in and asked if she shouldn't even have a little milk in her coffee and hour later and a bunch of people told her no, she couldn't! Yeah, right. They cite studies done and yes it's true that calcium is known to affect absorbtion, but another person wrote in clarifying that the studies used calcium in greatly exaggerated strengths, far greater than the average calcium supplement's strength.

I take Synthroid in the morning crushed in about 1/2 tsp applesauce , eat about 45 min later (my doctor even said 1/2 hour is fine) and take my vitamins after dinner.