((((((lavieenrose)))))) I can definitely relate to what you say here about dealing with these issues for decades and feeling now, later in life, that change may not be possible.........I've had anxiety issues and problems with dysthymia (chronic, low-moderate grade depression) on and off for about 30 years. Lately it's my anxiety which is causing me the most despair. Like you, I've had tons of therapy and tried every anti-depressant. Even worse, in my case, I actually have a very nice life, yet I still manage to feel anxious and depressed (which makes me feel guilty and ungrateful to boot).

I do think it's neurochemistry to a large extent, since there isn't anything in my life situation to warrant the degree of anxiety I experience. And I already do most of the "lifestyle" things that are recommended to boost mood (exercise, good diet, meditation, etc etc) I keep hoping there will be further advances in the field of psychiatric meds and just a better understanding of why some people respond to current drug therapies and others don't (and that more can be done to help those who don't!).

I'm so glad that you felt some relief yesterday by increasing your ADD meds. I really hope that boost lasts! Hugs to you! I'm glad you're here! I do find it comforting to talk to others who understand and I hope that helps you feel less alone too