I'm shocked at your initial dosage. I take Seroquil but I just upped my evening dosage (after being on the medication for a year) from 150mg to 200mg at night. I also take 25mg in the morning. I know there was a work-up period. They started me at 100mg at night to begin with and upped it to 150 after like 2 weeks. This seems like an extremely high dosage to start on. I second (or third) the call your doctor sentiment.