For me Wellbutrin XL is a first thing in the morning drug. If I take it too late in the day it will keep me from falling asleep. I am taking between 150 mg - 300 mg (up the dose if I am feeling extra unmotivated). Seroquel I take at night, I was on 200 mg immediate release for 2 years, but I was starting to feel it wear off by the end of the day, so we moved to 300 mg of the extended release.

The 300 mg Seroquel XR is less sedating than the 200 IR, but is much longer acting without the feeling of being dropped on my head by the end of the day.

Are you taking Wellbutrin XL or standard Wellbutrin, if it is XL then I would take it only once in the morning. If it is not the XL then due to the immediate release nature it is not uncommon to take upto 3 times in the day (separated by about 6hr) as it has a rather short half life.

If I am having trouble sleeping then I add something depending on why. If I am full of energy, melatonin... If it is racing thoughts and anxiety xanax. If that does not work I will take a lunesta.