make sure you are taking the prilosec at least an hour before taking the depakote. Prilosec takes about an hour to reduce acid and put a nice protective lining in the stomach. Also take the depakote with some food, stuff like toast or crackers. This helps absorb the acide that the stomach makes from the chemical reaction to the depakote. Try not to eat or drink anything a couple hours from when you go to bed. That will help kept the acid level in your stomach to a low amount. Try sleeping with extra pillows, keeping your head above stomach level. That too will help with getting the reflux so bad at night. I think you can take Prilosec twice a day, is prescription strength, not OTC (over the counter) dose. Check with your doctor if it becomes really bothersome, but it sounds it already has.