Positive? Negative? Neither. My Pdoc recommended that route when I was all against needing anything --ie. meds (as I was hypo and nearly bouncing off her couch.... ) They had no effect whatsoever for me. I can't remember dosages as it's been awhile, but can tell you I crashed hard and fast (after a particularly long hypomania) and was scrambling fast as the lowest and most desperate low was not all that long out of memory... and I knew exactly where I was going. It was meds for me.