Has anyone tried many different antidepressants over years with no results. I have tried so many along with therapy and it seems that nothing gives me the slightest relief . At the moment I am on nothing due to the last thing I tried Trazadone extended release to help regulate sleep and help with severe depression seemed to make me want to sleep 20 hours a day and depress me more and cause a sort of agoraphobia which I never had before and now am expierencing even though I have been off that med over 2 weeks now.Before that I had tapered off Pristique completely,tried effexor,celexa,prozac,paxil you name it for like 20 years .SSRI's,MAOI's,Tricyclics I am done .I am only 47 and ready to say give me the old labotomy I am sick and tired of being sick and tired and feeling down 80% of my life and losing people because of the time I can't make myself happy for them.