I take Cymbalta - 90mg. I have been as high as 120mg. I am a lucky person in that I rarely suffer from side effects. I don't know about Cymbalta but most side effects resolve in the first month or so (from what other people has said). I really like Cymbalta as it has definitely helped reduce my depressive episodes. And, the last time I got depressed I didn't even get suicidal, what a change!