Just an FYI, Wyeth filed today with the FDA for approval of a new version of Effexor that has been tweaked in unspecified ways. It's called desfenlaxafine and they have filed for treatment of major depressive disorder.

So, assuming the FDA gives the nod, there will be something else in the cupboard like Effexor (hopefully without the withdrawal issues) in something like 6 to 18 months.