I'm treated for low thyroid, and have tried every anti-depressant and various combinations for unipolar depression over a 30 year period, with little to no benefit. I hate sedation as a side effect, as I struggle with ADD and mental sluggishness as it is. I also fear the potential risk of tardive dyskinesia from atypical antipsychotics. I'm currently only on vyvanse for ADD. I wish there was something that would work, and wouldn't make me either anxious or dull and tired. It's so frustrating.