I have a question here .I have been taking ssri's many different ones over say 30 years none have worked ,my dx as far as i know has been MDD could it be possible I have been misdiagnosed and be bipolar.I don't have many highs so to speak once in a great while I can be up for 24 or 48 hours what I call wired and tired but not like overly confident or anything but maybe a little better mood.But more so I am overly fatigued and depressed feel helpless,hopeless etc..My depression has also costs me dear time and I believe my closest relationships due to being such a downer to be around..