Hi, welcome to PC. Your step son is VERY lucky to have you and your support.

I'm wondering, has he had any delusions before taking Effexor, and is he *still* having them? Knowing that might give you a clue as to whether the problem is from that med or not.

I know it is discouraging to have tried many meds and still not feeling well. Unfortunately, it's common for people to try a lot of different meds - individually and in combo. Perhaps he needs to take another med on top of his current one. Please keep in mind that some meds might not be effective until 6weeks or so.

I hope things will get better for him soon. Take care.