My experience has been that it makes me irritable and fogs me in mentally - I notice a fairly sharp decrease in cognitive function. After taking it (this is SR) for about 5 years I developed spasming things and a few other side effects that were severe enough to taper off it. Then I got really depressed about 3 weeks after the last dose and had to restart just before xmas. Now I am feeling better depression wise but also feeling that fogged-in mental thing -cognition and memory. Also lethargic, but that may be because my trazadone dosage was upped as I was tapering off the Wellbutrin. So far no re-emergence of the spasming side effects and I don't think I would describe myself as irritable.

I think I was overmedicated at 450 mg/day. So far 300 mg/day is doing the trick. Side effects are not too bad, although they are lowering my functioning a tad. I'm not irritable ... yet.

I like the drug because it has been around for quite a while and is generally relaitvely benign. For various reasons I don't like SSRIs or SNRIs.