A bit over a year and a half ago, I was 210lbs....now I've gotten down to 115. It can be done. If the combo is depakote and zyprexa, I'd ask to switch. I find that a low dose of depakote with abilify works. It hasn't put any weight on me since I resumed taking the drugs since last July....and to lose the weight I was on a 1,000 cal diet. I also heard that lamictal is the best for weight issues. You can do it!!!!