Do nothing else...say nothing else...just be there when the .... hits the fan, other wise you may find yourself without either sis nor her daughter...if this sounds harsh think how harsh it would be alienated from your fam damily...you've planted the seed now watch to see if it grows...maybe accidentily leave a pamphlet or two laying around...subtlty can be an eye opener...I apologize if I hurt you but in my opinion if you keep bombarding your sis with this she may react the wrong way...you sound like a caring and concerned sister...I too tried to explain to my sister that her kids were on the wrong path and we haven't spoken for a long time...it's hard when you care alot about a person whom you know is in need and you want to help but you can only do so much...let your sister know that you love her and will always be there for her and her daughter...in my opinion that's all you can do...