For the past several months, I was treated for depression with Effexor and the Cymbalta. These meds destabilized my mood so much that I was having hypomania, then deep waves of depression....suicidal thoughts, risky behavior. I ended up being hospitalized for two weeks and diagnosed with bipolar I. The pdoc explained that often if someone is treated for depression, but is really bipolar , antidepressants can often destabilize the mood. so, i'm on lithium and risperdal now...and feeling so much better.