I'm on 100mg of Zoloft, 75mg of Trazodone, 120 of Inderol (Propranolol for anxiety and flashbacks) plus I take 10mg of Flexeril (muscle relaxer) at night because of psycho somatic pain. As long as I take those meds at those exact doses I end up somewhat "normal"....but if I decrease ANY of those meds (except for the Flexeril) I end up anxious and experience an increase in PTSD, depression and anxiety symptoms. Until the Zoloft increase from 50mg to 100mg I had never been on 100mg of an antidepressant before. So, at first it did seem like a lot me....but I know that med combo at those doses is what I need in order to function normally...or as pretty close to normal as I can get. Thankfully my therapist doesn't question my medication when I tell her that it's been changed or increased. She knows my doctor and knows that the medications are my doctor's area of my treatment. Most therapists don't know that much, if anything about medications. And everyone is different and responds to different doses. While my aunt responds well to 50mg of Celexa (she just has clinical depression), I was taking 60mg of Celexa (as well as 60-80 mg of Inderol) which was the maximum dose my doctor could prescribe without me seeing a psychiatrist and the 60mg stopped working after a few months. Prior to that I had tried Paxil (20mg then 40mg of the old version of it and then 25mg of the Paxil CR) and I kept having adverse reactions to it (I was just as depressed on it as I was off of it and sometimes it would make me more depressed). Every 2 months or so I'd have to have the Celexa increased because I'd stop responding to it. So far the Zoloft and Trazodone combo is working great. Though I use the Trazodone more as a sleep aid than an anti-depressant.