Welcome ((((animasana))))) I know it's really hard, but, if at all possible, I would not take the sedative. You will feel soooo good afterwards if you get through the talk on your own steam. It will do wonders for your confidence! And you'll be able to build on that.
If it turns out you do have problems with anxiety while giving the talk, well, there is no shame in that and you could always take the sedative next time. But at least you will have tried.
I realize that either way you are trying and I really know what a big hurdle anxiety is. I'm rooting for you!!!

Good luck tomorrow!!!!!!!