I've been off anti-depressants for several years, as they didn't seem to work, and have slid into such a deep depression since then, that I'm thinking hard about meds again. I also wanted to "cure" myself with meditation, cognitive approaches, healthy lifestyle, etc., but now even a partial effect from anti-depressants sounds mighty good to me. Though, I'm ambivalent and still sitting on the fence. I agree with Rohag that any type of rejection can be very painful. I get very obsessed and set back by that. It can be necessary (for me too) to take a multi-pronged approach. Best wishes.