Sorry for the delay in getting back to this thread....

Propranolol is safe, but the issue with oral birth control is that SJW will increase the rate at which the synthetic hormone is broken down, reducing the blood concentration more quickly. So, the end result is as if you took a lower dose of the birth control hormone. It would be possible, I guess, to go to a higher dose product, but that would be guesswork. A back-up method is a better idea, probably.

Also, with respect to the issue of natural vs. synthetic. Almost everything we know about how to drug the body arises from our study of the effects of herbs and such on health. Do not make the mistake of thinking natural = better, or that natural = safer. Pharmaceutical drugs are very simple in one respect. They're a pure substances. Herbs, on the other hand, exert their effect(s) usually via multiple active ingredients, acting simultaneously. But nonetheless, herbs used as medicine should be given the same cautions used around pharmaceutical drugs. I could give you a natural herb that would kill you in seconds (hypothetically).

I think there are a lot of things people can do, to promote mental health, that are not drug-based. Modifying diet, for example, or supplementing with nutrients. But that's a separate issue from what I'm addressing, above.

Lar