i'm not a doctor, but i have to say that i dont think its the number of meds youre on that matters, but how youre feeling. i've been on as many as four at a time. at one point i felt like a zombie. i dont think it was the number of meds that was a problem, but the specific ones i was taking that just werent agreeing with my system. if youre feeling good, then youre probably doing something right. if not, you should bring it up with your doctor. i dont think its uncommon to be on a number of different medications. i think you just need to figure out if its working for you.