Hi Elana. I take Zoloft. My main problem is various forms of anxiety. My depression is secondary to the Anxiety Disorders. I find the Zoloft to be somewhat helpful with both. I can distinguish pretty clearly between my anxiety and my depression, but they are inter-related and I know what you mean about not knowing where one ends and the other starts. I do find generally that they are two pretty distinct - and in some ways opposite - types of energy though.