talk to his doc, maybe have him evaluated. have a serious conversation with him about how he is feeling and such, and try and include him and his opinions on whatever you try to do. a bunch of mental illnesses cause low motivation levels, insomnia/sleeping disturbances, and irritability- it could be a number of things, or just a weird phase- talk to the doctor about it!!
good luck.
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"Wounds heal and become scars. But scars grow with us" -Stanislaw Lec
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