Has the Seroquel ever worked for you, or is it this particular episode that it is messing with its effectiveness? You might need a different med because it could have the effect on you that I call the "Ritalin effect". Like how people with ADD/ADHD need an upper to bring them down, people who are already up might not respond right to a downer. My Mother took Celexa for her depression, but when she would get manic/mixed, it would just accelerate it 50x worse. I hope I could offer a little help! Keep us posted : )