Jen...I was going to say what pat said...check with the print-out on your med...there could be a difference depending on the med. I take a gazillion meds so I keep a notebook to write down the med and time I take each one so I know I've taken all of them. I don't always take them at the exact same time, though. Depending on when I get up, my morning meds may be taken at 6 am or 10 am. So far, no bad reaction from it.