One of the major side effects of seroquel is weight gain. I have been on it for over ten years and continue to struggle with that as well. I have bipolar disorder. Although, I am also on lithium which can make you gain weight too. I have, "fallen off the ban wagon" lately but for several years I ate extreamily healthy and jogged. Still couldn't lower the scale. However, it keeps me alive. If the dose is lowered, I struggle with both anxiety and depression. At times when I have been at the end of my rope, the doctor upped the dosage and it made me feel better. Can't live with it, can't live without it I guess.