I had a kitty that had heart and renal problems. He became so fearful of the tablets he would look at me with sadness and a please no more face. Who knows what these medications do to them in terms of side effects that they cant grumble about.

Animals arent the dumb things people think they are and they can certainly feel pain and discomfort. I reckon after 6mths of this combo my boy had realised that he had something funny happen to him after each time he had a tablet and became fearful of these so called helpers. In fact Im sure of it.

Perhaps try a holistic vet. I prefer them if I can/situ is right.