Most accounts of the combination of Prozac and MDMA (Ecstasy) describe a reduction of the effects normally attributed to MDMA. Some people experience an enhancement of effects, but that is believed to be fairly rare.

In animal studies, Prozac prevented neurotoxic damage caused by repeated (emphasis *repeated*) MDMA exposure, even if taken up to five hours after the MDMA was administered. Although a similar effect has not been demonstrated in humans (something about people not wanting to be "sacrificed" to allow their brain tissue to be put under a microscope), many club goers use Prozac when tripping in the belief it is protective. The dominant theory is that Prozac binds to receptors in the brain, blocking direct access to the neurotoxic metabolites of the MDMA, but I have not verified that.

I neither advocate nor condemn someone using the combination. I believe it to not be an increase in risk to do so.

But that totally sidesteps the issue that you don't know what is in a typical street drug tablet. You do know what is in the prescription Prozac. Any risk from being given some other drug under the belief that it was MDMA, is a separate concern.

Stopping the Prozac for a week would not eliminate the drug from the blood. I think it would be both unnecessary and pointless for your friend to stop taking Prozac.

Regards,
Lar