I use seroquel 300mg nightly and 600mg during PMS week and I'm lucky enough to sleep more than 6 hrs without waking up several times. With that I'm taking Xanax ER 2mg each night. I guess for me, its because I'm regularly on the manic side of the fence on a regular basis and when I swing high I'm out of control, With a Large dose of several resque meds. I have heard about seroquel be a knock out, wish it was that way for me.