I was also prescribed 100 mg Seroquel for my Bi-Polar disorder to calm the mania and help with my insomnia. When I first started, I woke up feeling full-on drunk for about 3-4 hours (right down to the walking into walls!) After a few weeks, the side effects subsided and I'm able to wake without the "drunk factor" as my MD & I joke about. Although, my next med check is this Friday, and I'm not sleeping...Ambien doesn't work for me, so I feel a dosage increase coming on. It's not so bad though, the 100mg worked pretty well for almost a year, it's just seemed to have pooped out on me the past couple of months.