I was on a birth controll pill for about 7 years. (One brand for 6 years, then I tried a lower estrogen pill for 1 year.) I started to have issues with heart palpatations, increased anxiety, mood swings, etc all about 2 weeks before my cycle. I was diagnosed with Pre-menstural Dysphoric Disorder about 2 years ago (I've been off the pill for 10 months now.) About 2 months after I went off the pill, my husband and I noticed I was still getting the PMDD symptoms but they were lasting days and not a week or two at a time, and I could manage them better. I rarely have cardiac symptoms now.
Did your wife's symptoms seem to increase right before her menstural cycle or does her mood significanlty change before her cycle?