Thanks for this. I think it's important for people to understand that antidepressants ARE helpful. In my case, finding the right antidepressant meant the difference between life and death for me. It's dangerous and irresponsible to suggest that they plain don't work (not to mention untrue -- I'm living proof!). The problem is that there is no fast and true rule for meds. They work differently for different people, and it can take a really long time to find the medication and/or dosage that works for you. It was while we were experimenting with my dosages that I felt the most hopeless, like nothing was ever going to work, but when the meds finally did kick in, boy did I notice a difference! I wish there were more articles explaining how antidepressants are tricky but ultimately worth it, because THAT is what depressed people need to hear, not that they have no hope of getting on a good medication.