I have been on meds for 20 years. Yeah, genetics--illness runs in my family. Have a sister and two nieces (sister's kids) who are bipolar and I'm diagnosed MDD, but wondering if I might be bipolar too. Brother and the other sister have chronic depression. Am not aware that I've ever had mania but I have been having a lot of trouble sleeping. And my depression is much, much better right now. My pdoc put me on Abilify, as well as my Cymbalta and Remeron and that has made a big difference I think and hubby thinks so too. I don't think I could ever be off meds and be normal--I was really ok, just tired when my GP figured out I had low brain chemicals (knowing my family history--great family doc!). He's the one who put me on the Prozac which served me well for about 20 years, till I had this latest bout of depression after some significant stressful episodes in my life.