I was on 300mg of wellbutrin, went up to 450 (the highest dose) and started having petite mal seizures even though I had no side effects on 300mg. Also, many insurance companies will not cover 450mg of wellbutrin because there is no 450mg pill... you have to take a 300 and a 150 or 3 150's.... a dumb insurance glitch but we had to fight like h*ll to get my insurance to cover mine. My pdoc added Zyprexa when things got nasty and that helped. There are a lot of atypical antipsychotics that boost the effects of wellbutrin. I have also used Abilify to boost the effects of my antidepressant.