Yes, darkangel, I've seen Seroquel prescribed pretty regularly for BPD. It is being used "off label" meaning that it wasn't what the drug was originally developed for by the drug company but prescribing psychiatrists gave it a try and found that it is sometimes helpful in stabilizing the mood of clients with BPD. Personally, I think it happened because psychiatrists will throw any drug but the kitchen sink (and sometimes the kitchen sink!) to clients with BPD because they're trying anything and anything to give their clients some relief. Personally, I haven't found medications to be at all helpful to me, with the exception of a six to eight month time period when I was in a severe depression. My dislike of Seroquel is that it pulled the "hungry" trigger of my brain BIG time! I wanted off that as soon as I realized that was what was going on for me when I was tried on it. I'm sure others will have some helpful responses.