Cetaphil, not the liquid, it's okay, but the creme in the plastic jar,helps a lot and there is no perfumes in it, so that's one last additive to irritate the skin.
I use to work in a wildlife center, and we'd wash our hands often,used some stuff to keep the infirmery clean, but between that,working outdoors,hands in literally freezing water, destroyed the skin on our hands big time. Cetaphil was great. If possible try to use a mild soap like the original Dove, Cetaphil makes one too. My dermatologist always recommended those. Also cream up your hands before bed and slip a white cotton glove(s) over them, that helps too.
Just some tidbits from the many others I have.

Take care,
DE