I am on Serquel XR as well. My pdoc said that Seroquel XR is slower releasing, so generally people don't experience the side effect of being tired as bad as they do for the regular Seroquel. I have mixed feelings about seroquel. I think it has helped me some, but the side effects aren't fun. I am hungry all the time, constipated (so much so that I am bloated and have stomach pain daily), and I feel hung-over all morning unless I get at least 11 -12 hours of sleep at night. I have stayed on it though because I think it has helped make my life somewhat bearable. You should talk to your pdoc about your concerns. He/She may be able to tell you a little more about it and why they prescribed it for you.