my clinical depression was lifted after i began taking an anti-depressant and a mood stablelizer. i still tended to have a tinge of depression with that mix. another was added. now-21 yrs. later i'm still fine. the only time i went under was when i didn't think i needed an anti-depressant. 21 days later i felt sui..with severe depression. my bad. yes, we can, i believe, live a happy, joyous life  if we get help. we need not suffer.
my situational depression was incredibly helped with therapy. i have the skills and tools now to rationally put things in a more positive perspection as a result of my therapy.
hope this helps and eases your concerns.
PS your wife's depression is her own. depression's not contagious.
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Do not let your fire go out, spark by irreplaceable spark, in the hopeless swamps of the approximate, the not-quite, the not-yet, the not-at-all. Do not let the hero in your soul perish, in lonely frustration for the life you deserved, but have never been able to reach. Check your road and the nature of your battle.
The world you desired can be won. It exists, it is real, it is possible, it is yours..~Ayn Rand
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