It can be scary to take a secondary medication because the side-effects of the primary medications are that bothersome or difficult to manage. I don't know if it makes you feel any better but cogentin is a fairly old medication and has remained in existence because of its success. Older medications are often replaced by newer ones to manage side-effects, so in my amateur view, when a fairly old medication is still being used, it indicates it has great success.

One of the things you want to watch out for, especially if you have current heart conditions is tachycardia (unusually fast heart rate). Also, excess amounts of cogentin can result in psychosis, so if you are on it and you experience psychosis, you want to see your doctor because either the cogentin dosage is too high or the anti-psychotic dosage is too low, or both.

I don't know if this will make you more comfortable or confuse you but Prestiq and Abilify use metabolic enzymes CYP3A4 and CYP2D6, whereas cogentin uses CYP2C19. "CYP" refers to a family of enzymes called Cytochrome P450. The overall point is you can know whether there will be a harmful medication interaction depending how the medications use the same CYP450 enzymes. If this part is too confusing, which it may be, the summary is cogentin should not negatively interact with your medications. Also, Prestiq and Abilify can somewhat enhance each other by the way they use the CYP450 enzymes.