Hi, Prozac really helps my depression. I also take Welbutrin. I am Bipolar 2, mostly depression. We recently added Ritalin to the mix to give me a boost in energy and the depression and it helped. I went a few months without being depressed at all. For my Bipolar, I take Lamictal, Topamax, and Abilify. I beleive the Topamax works very well and I know for sure that Abilfy works great for me, too. It really helped with my anger and agression when I became manic. Hope this helps.