Been on Seroquel for about almost a year and since then I went from 140lbs lean and cut to about 180lbs, muscles started disappearing behind the fat. I started eating larger portioned meals twice as much and lots of sweets. Now I been hitting the gym doing a lot of cardio, lifting weights, and trying to stay away from the sweets even though its hard. Now I'm down to 165lbs and seeing my V line once again!