Wellbutrin helped kick a serious bout of depression. After 12 months I hit my first major depressive episdode again. Not too bad considering how I used to cycle.

It isn't great for anxiety though - I get very anxious, worked up, and stress.
I have had a lot more hypomanic spells since being on wellbutrin too. Regardless, I don't think I'd stop taking. And it has really helped with the smoking too-lol