I have been on Topamax for 5 years. At first, I lost alot of weight, like a previous poster stated, down to anorexic state. I was fat though, from psyce meds. I liked it for that, but now the weight is coming back and I am stupid. I am in a fog alot of times. I am on disability for bipolar. I couldn't imagine having a job! I wouldn't be able to learn anything. I take 150mg, so it's not a huge amount either. I does stabilise my moods, however. It does that job well. I would not see myself coming off it. I'll be stable and stupid. Better that than bright and psychotic!