Thank you all so much for your replies! It means a great deal to me, sorry I haven't updated lately. Here's a little update. I have been on Seroquel for about a month now. The first two weeks I was on 25-50 mgs. At first it worked great, and gradually the effect was less and less. I had my follow up appt. with pdoc, she upped my dose to 100-200 mgs per night at bedtime. I am working on upping it, but since I still have a bunch of 25 mg pills left, for three days I have been doing 75 mgs. I am going to do that until my 25 mgs are gone, then I will up to the 100 mg pills. I don't want to be too out of it,because I have two little ones, and need to be able to be roused if they awake in the night. pdoc wants to get me up to 300 mgs, because that is the therapeutic dose. As far as weight goes, I have actually lost 15 lbs while taking this, because instead of being up half the night munching, I actually go to bed at a decent time and am not snacking all night while I can't sleep. I hope when I up my dose, that doesn't change, because I am already overweight as it is.