I just got up to 200 mgs. after several weeks, and boy was I waiting for it to kick in. Looking back, ( I also keep a "mood chart"), I started coming around at 75 mgs. and felt significantly better at 100 mgs. I love that it doesn't make me feel dopey or spacey or tired---just much better than the pit of depression I was in. I'm feeling more balanced and stable than I can remember. Thank God for Lamictal!