There is no research on the effects of alcohol on many of the meds. On escitalopram, i drink alcohol, and it seems to be fine. I know Effexor is supposed to be okay with alcohol. When i took Seroquel (quetiapine) i felt as if it made me feel awful the next day with alcohol. If you only have two drinks e.g. 1/3 bottle wine, it should be fine unless you are specifically warned not to. Even then, the doctor may be overly cautious and unrealistic - you need to ask if they actually know about the effects of alcohol on the drug.