Morethingswrong: I'm sorry you are having such bad side effects. I was diagnosed over 20 years ago with chronic depression and anxiety disorder and during that time I went through 53 different drug trials. Then they finally decided I was treatment resistant. One thing I learned is that just because we are given a certain drug doesn't mean we can't speak up and say just how horrible the side effects are - they usually outweigh the good effects. Not everyone tolerates seroquel well, and there are a lot of options out there. I ended up staying with the best cocktail that helped me and I'll be damned if I let any other Pdoc change my meds around without a very good reason. I'm just on maintenance and it's better than being a guinea pig for all the new drugs on the market. Sometimes Pdocs get all these samples and tend to give them out too easily. Sorry to vent, but it drives me crazy too.